TAK-438 ntụ ntụ (1260141-27-2) ntụ ntụ - Nrụpụta ihe na-emepụta ihe
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TAK-438

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TAK438, nke a makwaara dị ka Vonoprazan Fumarate, bụ ọgwụ ọhụrụ maka ịgwọ ọrịa ndị metụtara acid nwere usoro ihe eji arụ ọrụ nke akpọrọ potassium-competitive acid blockers (P-CABs) nke na-eme asọmpi na-egbochi njikọ ion potassium na H +, K + -ATPase ( nke a makwaara dị ka proton pump) na nkwụsị ikpeazụ nke gastric acid secretion na mkpụrụ ndụ gastric parietal, na-achịkwa gastric acid secretion. Ọ na - enye nsonaazụ inhibit acid siri ike ma kwagide ya.

Product Description

Njirimara Nhazi

Product Name TAK-438 ntụ ntụ
CAS Number 1260141-27-2
molekụla Formula C21H20FN3O6S
Ụdị Ụdị 461.46
Synonyms Vonoprazan Fumarate;
TAK-438 ntụ ntụ;
1260141-27-2;
Vonoprazan fumurate;
NWE 438.
ọdịdị White na-acha ọcha ntụ ntụ
Nchekwa na Ijikwa Akọrọ, ọchịchịrị na 0 - 4 C maka obere oge (ụbọchị ruo izu) ma ọ bụ -20 C maka ogologo oge (ọnwa ruo afọ).

 

TAK-438 ntụ ntụ Nkọwa

TAK438, nke a makwaara dị ka Vonoprazan Fumarate, bụ ọgwụ ọhụrụ maka ịgwọ ọrịa ndị metụtara acid nwere usoro ihe eji arụ ọrụ nke akpọrọ potassium-competitive acid blockers (P-CABs) nke na-eme asọmpi na-egbochi njikọ ion potassium na H +, K + -ATPase ( nke a makwaara dị ka proton pump) na nkwụsị ikpeazụ nke gastric acid secretion na mkpụrụ ndụ gastric parietal, na-achịkwa gastric acid secretion. Ọ na - enye nsonaazụ inhibit acid siri ike ma kwagide ya.

N'ime ogba afọ ndị a zụlitere, TAK-438 ntụ ntụ na-eme ka mgbochi acid dị ogologo na ike. Mmetụta mgbochi nke TAK-438 ntụ ntụ na nzuzo acid yiri ka ọ ga-ejikọta ya na physiology cell parietal cell.

 

TAK-438 ntụ ntụ Nhazi nke Action

TAK-438 ntụ ntụ (Vonoprazan fumarate) bụ ihe onyinye pyrole na potassium-asọmpi acid mgbochi (P-CAB) nke na-asọmpi na-egbochi ebe nrụọrụ potassium nke gastric H (+), K (+) - ATPase, isi enzyme na usoro nke gastric acid secretion. Ngwakọta ahụ nwere ike ịgbakọta na gburugburu acid ma kwesịrị inye ogologo oge mgbochi n'ihi pKa alkaline nke 9.06.

N'ime ogba afọ ndị a zụlitere, TAK-438 ntụ ntụ na-eme ka mgbochi acid dị ogologo na ike. Mmetụta mgbochi nke TAK-438 ntụ ntụ na nzuzo acid yiri ka ọ ga-ejikọta ya na physiology cell parietal cell.

 

TAK-438 ntụ ntụ Ngwa

TAK-438 ntụ ntụ (Vonoprazan fumarate ma ọ bụ Vonoprazan) bụ ọgwụ ọhụrụ maka ịgwọ ọrịa ndị metụtara acid nwere usoro ọrụ ọhụụ a na-akpọ potassium-competitive acid blockers (P-CABs) nke na-eme asọmpi na-egbochi njikọ nke potassium ion na H +, K + - ATPase (nke a makwaara dị ka proton pump) na njedebe ikpeazụ nke gastric acid secretion na mkpụrụ ndụ parietal gastric. A kwadoro ọgwụ ahụ na Japan maka ọgwụgwọ ọrịa ndị metụtara acid, gụnyere ọnya afọ, ọnya duodenal, reflux esophagitis na Adjunct na mkpochapu Helicobacter pylori n'ihe banyere ọrịa Helicobacter pylori.

 

TAK-438 ntụ ntụ mmetụta & ịdọ aka ná ntị

Mmetụta ndị nkịtị gụnyere:

▪ afọ ọsịsa,

▪ ọgbụgbọ na ọgbụgbọ,

Afọ ntachi,

▪ mgbu afọ,

Rash ọkụ ọkụ,

Nrekasi obi.

 

Ihe ndị a abụghị mmetụta mmetụta niile TAK438 nwere ike. Maka ama ndị ọzọ, jụọ dọkịta gị ma ọ bụ onye na-ere ọgwụ. Kpọọ dọkịta gị maka ndụmọdụ ahụike gbasara mmetụta ndị ọzọ. Nwere ike ịkọ akụkọ gbasara FDA na 1-800-FDA-1088.

 

Reference

[1] Arikawa Y, Nishida H, Kurasawa O, Hasuoka A, Hirase K, Inatomi N, Hori Y, Matsukawa J, Imanishi A, Kondo M, Tarui N, Hamada T, Takagi T, Takeuchi T, Kajino M. Nchọpụta nke akwukwo pyrrole akwukwo 1- [5- (2-fluorophenyl) -1- (pyridin-3-ylsulfonyl) -1H-pyrrol-3-yl] -N-methylmethanamin e fumarate (TAK-438 powder) dị ka potassium-asọmpi ihe ngbochi acid (P-CAB). J Med Chem. 2012 Mee 10; 55 (9): 4446-56. ma ọ bụ: 10.1021 / jm300318t. Epub 2012 Apr 30. PubMed PMID: 22512618.

[2] Kondo M, Kawamoto M, Hasuoka A, Kajino M, Inatomi N, Tarui N. Nnyocha nyocha dị elu nke ndị na-egbochi acid-asọmpi acid. J Biomol ihuenyo. 2012 Feb; 17 (2): 177-82. ma ọ bụ: 10.1177 / 1087057111421004. Epub 2011 Sep 22. PubMed PMID: 21940711.

[3] Shin JM, Inatomi N, Munson K, Strugatsky D, Tokhtaeva E, Vagin O, Sachs G. Njirimara nke akwụkwọ mpịakọta acid-asọmpi acid nke gastric H, K-ATPase, 1- [5- (2- fluorophenyl) -1- (pyridin-3-ylsulfonyl) -1H-pyrrol-3-yl] -N-methylmethanamin e monofumarate (TAK-438 ntụ ntụ). J Pharmacol Exp Ther. 2011 Nov; 339 (2): 412-20. ma ọ bụ: 10.1124 / jpet.111.185314. Epub 2011 Aug 9. PubMed PMID: 21828261; PubMed Central PMCID: PMC3199995.

[4] Hori Y, Matsukawa J, Takeuchi T, Nishida H, Kajino M, Inatomi N. Nnyocha na-atụle mmetụta antisecretory nke ntụ ntụ TAK-438, akwụkwọ akụkọ potassium-asọmpi acid na-egbochi ya, na lansoprazole na ụmụ anụmanụ. J Pharmacol Exp Ther. 2011 Jun; 337 (3): 797-804. ma ọ bụ: 10.1124 / jpet.111.179556. Epub 2011 Mar 16. PubMed PMID: 21411494.

[5] Matsukawa J, Hori Y, Nishida H, Kajino M, Inatomi N. A comparative ọmụmụ na ụdịdị nke edinam nke TAK-438 ntụ ntụ, a akwụkwọ akụkọ potassium-asọmpi acid mgbochi, na lansoprazole na isi zụlitere oke bekee gastric glands. Biochem Pharmacol. 2011 Mee 1; 81 (9): 1145-51. ma ọ bụ: 10.1016 / j.bcp.2011.02.009. Epub 2011 Mar 1. PubMed PMID: 21371447.

[6] Hori Y, Imanishi A, Matsukawa J, Tsukimi Y, Nishida H, Arikawa Y, Hirase K, Kajino M, Inatomi N. 1- [5- (2-Fluorophenyl) -1- (pyridin-3-ylsulfonyl) -1H-pyrrol-3-yl] -N-methylmethanamin e monofumarate (TAK-438 ntụ ntụ), akwụkwọ akụkọ na ike potassium-asọmpi acid mgbochi maka ọgwụgwọ nke ọrịa metụtara acid. J Pharmacol Exp Ther. Ọkt 2010; 335 (1): 231-8. ma ọ bụ: 10.1124 / jpet.110.170274. Epub 2010 Jul 12. PubMed PMID: 20624992.