Pregabalin ntụ ntụ

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Characters Basic Raw Pregabalin ntụ ntụ

Kedu ihe bụ Pregabalin Powder?

Pregabalin ntụ ntụ bụ ọgwụ nke klas nke gabapentinoids, nke na-arụ ọrụ site na igbochi ụfọdụ ọwa calcium. Ọ na-ejikọta na mpaghara α2δ nke ụfọdụ ọwa calcium voltaji-gated (VDCCs) na usoro nhụjuanya nke etiti ma na-eme ihe dị ka ihe mgbochi nke VDCC nwere α2δ subunits. Ọ bụ ezie na ọ bụ analọgụ gamma-aminobutyric acid (GABA), ọ naghị ejikọta ndị na-anabata GABA, ọ dịghịkwa agbanwe na GABA ma ọ bụ GABA ọzọ agonist na-anabata GABA na vivo ma ọ bụ na-achịkwa GABA njem ma ọ bụ metabolism.

Kedu ihe bụ Mechanism nke Pregabalin ntụ ntụ

Aghọtaghị usoro nke pregabalin nke ọma, mana ekwenyere na ọ ga-ebelata ntọhapụ nke neurotransmitters dị iche iche na-adabere na calcium site na igbochi ọrụ nke ọwa calcium, si otú ahụ belata mgbaàmà, n'ihi na pregabalin nwere ike jikọta ya na nnukwu mmekọrịta na ngalaba α2δ, nke. bụ ihe enyemaka nke calcium-gated channel na Central nervous cell. Nsonaazụ nke mgbanwe ọmụmụ òké na nnwale na ogige ndị dị ka pregabalin gosipụtara na pregabalin na-ejikọta na saịtị α2-δ ma nwee ike igbochi mgbu na ọdịdọ na ụdị anụmanụ na pregabalin. . Nnwale in vitro egosila na pregabalin nwere ike belata ntọhapụ nke neurotransmitters dị iche iche na-adabere na calcium site na igbochi ọrụ nke ọwa calcium, si otú ahụ na-agwọ na ibelata mgbaàmà.

Kedu uru nke Pregabalin ntụ ntụ?

Uru nke pregabalin ntụ ntụ gụnyere:

① Mbelata mgbu Neuropathic

Edepụtara Pregabalin dị ka ọgwụ mbụ maka ọgwụgwọ ọrịa neuropathy na-arịa ọrịa shuga, neuralgia postherpetic ezubere iche, na mgbu neuropathic etiti. Nnyocha egosiwo na a na-ejikọta doses dị elu nke pregabalin na arụmọrụ ka ukwuu. Ọ bụ ezie na iji pregabalin maka mgbu neuropathic metụtara ọrịa kansa bụ arụmụka, a na-ejikarị ya eme ihe. Ọzọkwa, enyochala ya maka mgbochi nke mgbu na-adịghị ala ala mgbe ịwa ahụ gasịrị.

② Mgbochi mgbochi

Pregabalin bụ analọgụ gamma-aminobutyric acid (GABA) nwere usoro na omume yiri nke gabapentin na ọrụ antiepileptik. Ọ bụ ezie na a maghị usoro antiepileptic nke pregabalin, nchọpụta ụlọ nyocha egosila na pregabalin nwere ọrụ anticonvulsant n'ụdị ọrịa akwụkwụ dị iche iche. Ọ bụ ezie na ụdịdị ọrụ dị iche iche nke ụdị anụmanụ yiri nke gabapentin, pregabalin na-arụ ọrụ ugboro 3-10 karịa gabapentin.

③ Enyemaka Nchegbu

A na-atụ aro Pregabalin dị ka otu n'ime ọgwụ ndị bụ isi maka enyemaka nchekasị. Ọ na-arụ ọrụ nke ọma ma dịkwa mma maka ọgwụgwọ nsogbu nchekasị zuru oke. Ọ dịkwa irè na ọgwụgwọ dị mkpirikpi na ogologo oge nke nsogbu nchekasị nke ọha na eze yana ibelata nchekasị tupu ịwa ahụ.

④ Ojiji ndị ọzọ

Mgbe ụfọdụ, a na-enye ndị nwere nsogbu bipolar iwu lPregabalin.
Nnyocha egosiwo na pregabalin nwere ike ịgwọ migraine nke ọma.

Kedu ihe mmetụta dị na Pregabalin Powder

Mmetụta dị n'akụkụ pregabalin yiri nke ndị ọzọ na-ada mbà n'obi nke usoro ụjọ ahụ. Mmeghachi omume ọgwụ ọjọọ metụtara iji pregabalin gụnyere:

• A na-ahụkarị (> 10%): isi ọwụwa, ụra.
• A na-ahụkarị (1-10%): ọhụụ na-agbagwoju anya, diplopia, agụụ na-abawanye na oke ibu na-esote, euphoria, mgbagwoju anya, wdg.
• Ihe na-adịghị ahụkebe (0.1-1%): hypoglycemia, ihe ọkụ ọkụ, mgbaka akwara, myalgia, arthralgia, thrombocytopenia, nkume akụrụ, wdg.
• Obere (<0.1%): neutropenia, hypotension, ọbara mgbali elu, pancreatitis, oliguria, rhabdomyolysis, echiche igbu onwe ma ọ bụ omume.

Otu esi ewere ntụ ntụ pregabalin

• Oge:Were pregabalin ntụ ntụ na ma ọ bụ na-enweghị nri n'otu oge kwa ụbọchị. Pregabalin kwesịrị ka a na-ewere ya mgbe niile, ọ bụghị naanị mgbe mgbu akwara na-akawanye njọ.
• Machie ma ọ bụ zere mmanya na-aba n'anya mgbe ị na-ewere pregabalin:Ịṅụ mmanya na-aba n'anya pregabalin nwere ike ime ka ndị mmadụ na-arahụ ụra, ike ọgwụgwụ, ma ọ bụ isi ọwụwa, ma mee ka ohere ịdaba dịkwuo elu.
• Ọgwụ efu efu:Ọ bụrụ na echefuru iwere ya, were ya ozugbo n'echi ya. Ma ọ bụrụ na ọ fọrọ nke nta ka ọ bụrụ oge maka ọgwụ ọzọ (n'ime awa 4), were ọgwụ ọzọ n'oge kwesịrị ekwesị. Ejila ọgwụ abụọ.
• Mgbu mgbu anaghị adị ngwa ngwa: Were pregabalin maka mgbu, ọ naghị ewepụ ihe mgbu ozugbo. Ọ nwere ike were ụbọchị ole na ole ka mgbu ahụ kwụsịlata.
• Kwụsị pregabalin nwayo: Ọ bụrụ na ị chere na pregabalin anaghị arụ ọrụ, akwụsịla iwere ya na mberede n'ihi na ịkwụsị ọgwụgwọ na mberede nwere ike ịkpata mmetụta. Ọ na-akacha mma iji nwayọọ kwụsị pregabalin.

Otu esi achọta ezigbo onye na-ebubata ntụ ntụ Pregabalin n'ịntanetị?

Ọtụtụ ndị na-ebubata ya na-enye ntụ ntụ pregabalin ma n'ịntanetị na ụlọ ahịa anụ ahụ n'ụwa niile, mana ọ dị mkpa ịkpachara anya mgbe ị na-azụta iji hụ na ị nwetara ngwaahịa dị elu nke na-enye nsonaazụ dị mma. Ọ bụghị ndị niile na-eweta ngwaahịa na-ekwu na ha na-ere pregabalin ntụ ntụ dị ọcha bụ ezigbo, ebe ụfọdụ nwere mmasị na-enweta ego na ọ bụghị nsonaazụ ị nwetara site na ọgwụ ahụ. Ọ dị mma ka ịme nyocha nke ọma tupu ịzụrụ ihe ọ bụla, gụnyere inyocha nyocha ndị ahịa na ọkwa ụlọ ọrụ iji ghọta ọrụ ndị na-ebubata ya nke ọma.

Companylọ ọrụ anyị, aasraw, bụ onye na-eweta pregabalin ntụ ntụ na-ebubata na onye nrụpụta na mpaghara ahụ, yana ebe nrụọrụ weebụ nwere enyi na-enye gị ohere itinye iwu nke ọma site na iji ngwaọrụ ọ bụla. Anyị na-agba mbọ ịnye ngwaahịa anyị ngwa ngwa, ma ị nwere ike ịzụta ntụ ntụ n'ọtụtụ ma ọ bụ nke dabara na mkpa azụmahịa gị. Agbanyeghị, ọ dị mkpa iburu n'uche na ịgaghị ebido were pregabalin na-enweghị ntuziaka nke ọkachamara ahụike, n'agbanyeghị etu ị ga-esi zụta ya ngwa ngwa.

HNMR

Kedu ihe bụ HNMR na gịnị ka ụdịdị HNMR na-agwa gị? H Nuclear Magnetic Resonance (NMR) spectroscopy bụ usoro nyocha kemịkalụ ejiri na njikwa mma na nyocha maka ịchọpụta ọdịnaya na ịdị ọcha nke ihe nlele yana usoro ihe omimi ya. Dịka ọmụmaatụ, NMR nwere ike nyochaa ngwakọta nke nwere ogige ndị ama ama. Maka ogige ndị amabeghị, enwere ike iji NMR dakọtara megide ọba akwụkwọ ọpụrụiche ma ọ bụ tụnye usoro ntọala ozugbo. Ozugbo a mara usoro nhazi ahụ, enwere ike iji NMR chọpụta ngbanwe nke mkpụrụ ndụ na ngwọta yana ịmụ ihe anụ ahụ na ọkwa molekụla dị ka mgbanwe mgbanwe, mgbanwe oge, solubility, na mgbasa.

Pregabalin ntụ ntụ (148553-50-8) -COA

Pregabalin ntụ ntụ (148553-50-8) -COA

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Reference

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[2] Calandre EP, Rico-Villademoros F, Slim M (Nọvemba 2016). "Alpha2delta ligands, gabapentin, pregabalin na mirogabalin: nyocha nke ọgwụ ọgwụ ha na ọgwụgwọ ọgwụgwọ." Nyocha ndị ọkachamara banyere Neurotherapeutics. 16 (11): 1263–1277 .

[3] Finnerup NB, Sindrup SH, Jensen TS (September 2010). "Ihe akaebe maka ọgwụgwọ ọgwụ ọgwụ mgbu neuropathic". Mgbu. 150 (3): 573–581 .

[4] Clarke H, Bonin RP, Orser BA, Englesakis M, Wijeysundera DN, Katz J (August 2012). "Mgbochi nke mgbu postsurgical na-adịghị ala ala site na iji gabapentin na pregabalin: nyocha nhazi usoro na meta-analysis." Anesthesia na analgesia.

[5] Bandelow B, Wedekind D, Leon T (July 2007). "Pregabalin maka ọgwụgwọ nke nsogbu nchekasị zuru oke: ntinye aka na nkà mmụta ọgwụ." Nyocha ndị ọkachamara banyere Neurotherapeutics. 7 (7): 769–781 .

[6] Calandre EP, Garcia-Leiva JM, Rico-Villademoros F, Vilchez JS, Rodriguez-Lopez CM. Pregabalin na ọgwụgwọ migraine na-adịghị ala ala: ọmụmụ ihe na-emeghe. Clin Neuropharmacol. 2010 Jan-Feb;33(1):35-9 .

[7] Millar J, Sadasivan S, Weatherup N, Lutton S (Septemba 7, 2013). "Ụbọchị Lyrica - Mmegbu Pregabalin ntụrụndụ na Ngalaba Mberede Obodo". Akwụkwọ akụkọ ọgwụ mberede. 30 (10): 874.2–874 .

[8] Tanyıldız B, Kandemir B, Mangan MS, Tangılntız A, Göktaş E, Şimşek S (October 2018). "Mpụpụ Serous Macular nke abụọ mgbe ha nwara igbu onwe ya na Pregabalin". Akwụkwọ akụkọ Turkish nke Ophthalmology. 48.

[9] Desai A, Kherallah Y, Szabo C, Marawar R (Maachị 2019). "Gabapentin ma ọ bụ pregabalin butere myoclonus: usoro ikpe na nyocha akwụkwọ." Akwụkwọ akụkọ nke Clinical Neuroscience. 61: 225–234 .

[10] Stahl SM, Porreca F, Taylor CP, Cheung R, Thorpe AJ, Clair A (June 2013). "Omume ọgwụgwọ dị iche iche nke pregabalin: ọ bụ otu usoro na-ahụ maka ọtụtụ ọrụ ọgwụ?". Ọdịmma na Sayensị Pharmacological. 34 (6): 332–339 .

[11]Kedu homonụ a na-ejikarị eme mgbanwe maka mmekọahụ (ikike)

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