Mmiri MMAF (Hydrochloride) (1415246-68-2) HPLC≥98% | AASraw
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MMAF (Hydrochloride) (1415246-68-2)

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AASraw nwere njikọ na mmepụta site na gram ka usoro iwu nke MMAF (Hydrochloride) (CAS 1415246-68-2), n'okpuru usoro CGMP na usoro nchịkọta mma.

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MMAF (Hydrochloride) video

 

 


 

MMAF (Hydrochloride) bụ isi ihe

 

aha: MMAF (Hydrochloride)
CAS: 1415246-68-2
Usoro Molecular: C39H66ClN5O8
Molekụla arọ: 768.42
Melt Point: 314.3 Celsius C na 760 mmHg (Eburo)
Nchekwa Nche: Powder -20 ° C 3 afọ
4 Celsius C 2 afọ
Na ihe mgbaze -80 Celsius C 6 ọnwa
-20 ° C 1 ọnwa
agba: White crystalline ntụ ntụ

 


 

MMAF (Hydrochloride) eji eme ihe na steroid

 

aha

MMAF (Hydrochloride) (1415246-68-2) na-akpọkwa Monomethylauristatin F Hydrochloride, MMAF HCL

 

MMAF (Hydrochloride) Ugboro

Ọkà mmụta sayensị ọgwụ nwere ọtụtụ ihe gbasara MMAF, ebe a bụ ihe ụfọdụ maka nkọwa:
Na Vitro: MMAF na - egosi cytotoxicity na vitamin in vitro megide otu panel nke cell lines. Ihe IC50 maka Karpas 299, H3396, 786-O na Caki-1 bụ 119, 105, 257, na 200 nM, n'otu n'otu. MMAF a kwadoro dị ike karịa ọgwụ n'efu, na cAC10 conjugates nke MMAF gosipụtara ọrụ. N'ihe dị mkpa, cAC10-L1-MMAF4 bụ nkezi nke karịrị 2200-fold karịa ike MMAF ma na-arụsi ọrụ ike na CD30-positive cell lines tested

Na Vivo: Mkpụrụ kachasị anabata na ụmụ oke nke MMAF (1415246-68-2) (> 16 mg / kg) dị elu karịa MMAE (1 mg / kg). CAC10-L1-MMAF4 nwere MTD nke 50 mg / kg na ụmụ oke na 15 mg / kg na oke. CAC10-L4-MMAF4 ADC kwekọrọ ekwekọ na-egbu egbu, na-enwe MTDs na oke na oke nke> 150 mg / kg na 90 mg / kg na oke, n'otu n'otu

 

Ịdọ aka ná ntị na MMAF (Hydrochloride)

Maka nyocha eji naanị

 

Ntuziaka ọzọ

Edere na Monomethylauristatin F Hcl (MMAF Hcl) bụ onye na-emegide antitubulin nke na-egbochi nkewa cell site na igbochi polymerization nke tubulin; na ihe a na-eme na-abaghị uru karịa MMAE; ma ọ bụ mgbochi ọgwụ cytotoxin.

Achịcha Cell
A na-emeso mkpụrụ ndụ na ọnụọgụ ọnụọgụ nke mkpụrụ ndụ ule ma tinye ụbọchị 4-6 dabere na akara sel. Nyocha nke uto cellular na mbelata data iji mepụta ụkpụrụ IC50 na-eji nyocha Alamar Blue mbelata
MCE ekwenyeghi na nkwenye nke ụzọ ndị a. Ha bụ naanị maka nkọwa.

Nchịkwa anụmanụ
Iceké: ọmụmụ ihe na-egosi na mgbe ụyọkọ akpụ dị na Karpas 299 buru ibu ruru 300 mm3, anụmanụ atọ n'otu otu na-enweta otu ọgwụ nke ọgwụ mg 10 mg / kilogram nke ma ọ bụ cAC10-L1-MMAF4 ma ọ bụ cBR96-L1-MMAF (1415246-68-2) 4) intravenously. A na - ewepu etuto ahụ ma debe ya na ezigbo ọnọdụ ọkụ, na akụkụ anụ ahụ 5 -m-thin frozen na - ntụ ntụ site na iji nyocha immunohistochemistry
MCE ekwenyeghi na nkwenye nke ụzọ ndị a. Ha bụ naanị maka nkọwa.

 


 

Esi zụta MMAF; zụta Hydrochloride si AASraw

 

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