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MMAF (Hydrochloride) (1415246-68-2)

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MMAF (Hydrochloride) video


MMAF (Hydrochloride) bụ isi ihe

aha: MMAF (Hydrochloride)
CAS: 1415246-68-2
Molekụla Formula: C39H66ClN5O8
Ọbara arọ: 768.42
Melt Point: 314.3 Celsius C na 760 mmHg (Eburo)
Nchekwa Nche: Powder -20 ° C 3 afọ
4 Celsius C 2 afọ
Na ihe mgbaze -80 Celsius C 6 ọnwa
-20 ° C 1 ọnwa
agba: White crystalline ntụ ntụ


MMAF (Hydrochloride) eji eme ihe na steroid

aha

MMAF (Hydrochloride) (1415246-68-2) na-akpọkwa Monomethylauristatin F Hydrochloride, MMAF HCL

MMAF (Hydrochloride) Ugboro

Ọkà mmụta sayensị ọgwụ nwere ọtụtụ ihe gbasara MMAF, ebe a bụ ihe ụfọdụ maka nkọwa:
Na Vitro: MMAF na - egosi cytotoxicity na vitamin in vitro megide otu panel nke cell lines. Ihe IC50 maka Karpas 299, H3396, 786-O na Caki-1 bụ 119, 105, 257, na 200 nM, n'otu n'otu. MMAF a kwadoro dị ike karịa ọgwụ n'efu, na cAC10 conjugates nke MMAF gosipụtara ọrụ. N'ihe dị mkpa, cAC10-L1-MMAF4 bụ nkezi nke karịrị 2200-fold karịa ike MMAF ma na-arụsi ọrụ ike na CD30-positive cell lines tested

Na Vivo: Ngo kachasị na ụmụ oke nke MMAF (1415246-68-2) (> 16 mg / kg) dị elu karịa MMAE (1 mg / kg). cAC10-L1-MMAF4 nwere MTD nke 50 mg / kg na ụmụ oke na 15 mg / kg na oke. CAC10-L4-MMAF4 ADC kwekọrọ na ya bụ obere nsí, nwere MTDs na ụmụ oke na oke nke> 150 mg / kg na 90 mg / kg na oke,

Ịdọ aka ná ntị na MMAF (Hydrochloride)

Maka nyocha eji naanị

Ntuziaka ọzọ

Edere na Monomethylauristatin F Hcl (MMAF Hcl) bụ onye na-emegide antitubulin nke na-egbochi nkewa cell site na igbochi polymerization nke tubulin; na ihe a na-eme na-abaghị uru karịa MMAE; ma ọ bụ mgbochi ọgwụ cytotoxin.

Achịcha Cell
A na-agwọ sels na dilution serial nke mkpụrụ ndụ ule na oge 4-6 gbakwunyere na-adabere na mkpụrụ ndụ sel. Nyocha nke ntinye mkpụrụ ndụ na ntinye data iji wepụta ihe IC50 na-eme site na iji mgbarụ na-acha uhie uhie Alamar
MCE ekwenyeghi na nkwenye nke ụzọ ndị a. Ha bụ naanị maka nkọwa.

Nchịkwa anụmanụ
Ụmụ oke: ọmụmụ na-egosi na mgbe ntanetị nke Karpas 299 ruru 300 mm3, ụmụ anụmanụ atọ na-enweta otu ọgwụ nke 10 mg antibody mpaghara / kg ibu ahụ nke cAC10-L1-MMAF4 ma ọ bụ cBR96-L1-MMAF (1415246-68-2 ) 4 na intravenously. A na-ewepụ tumors ma tinye ya na ezigbo okpomọkụ okpomọkụ, na akụkụ 5 μm-mkpa nke anụ ahụ na-egbuke egbuke site na iji nyocha nke immunohistochemistry
MCE ekwenyeghi na nkwenye nke ụzọ ndị a. Ha bụ naanị maka nkọwa.


Esi zụta MMAF; zụta Hydrochloride si AASraw

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