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IDFP (615250-02-7)

Rating: SKU: 615250-02-7. Category:

AASraw nwere njikọ na ikike mmepụta site na gram ka usoro nchịkọta nke IDFP (615250-02-7), n'okpuru usoro CGMP na usoro nchịkwa mma.

Product Description

 

Video IDFP

 

 


 

IDFP isi agwa:

 

aha: IDFP
CAS: 615250-02-7
Usoro Molecular: C15H32FO2P
Molekụla arọ: 294.391
Melt Point:
Nchekwa Nche: -20 ° C
agba:

 


 

IDFP (615250-02-7) okirikiri

 

aha

Aha aha: ISOPROPYL DODECYLFLUOROPHOSPHONATE
Mmekọrịta:
IDFP; ISOPROPYL DODECYLFLUOROPHOSPHONATE; P-DODECYL-1-METHYLETHYL ESTER-PHOSPHONOFLUORIDIC ACID

 

IDFP (615250-02-7) Njikere

IDFP bụ ngwa organophosphorus metụtara akwara na-ahụ maka sarin. Dị ka sarin, IDFP bụ ihe mgbochi a na-apụghị ịgbagha agbagha maka ọtụtụ enzymes dị iche iche nke na-arụkarị iji mebie neurotransmitters, Otú ọ dị, ogologo ogologo alkyl nke IDFP na-eme ka ọ bụrụ nke na-esighi ike dịka onye na-egbochi acetylcholinesterase (AChE), yana IC50 nke naanị 6300nM, ebe ọ bụ onye na-eme ihe ike nke enzymes abụọ monoacylglycerol lipase (MAGL), isi enzyme nke na-emebi endocannabinoid 2-arachidonoylglycerol (2-AG), na fatty acid amide hydrolase (FAAH), enzyme bụ isi nke na-eweda isi endocannabinoid anandam . IC50 nke IDFP bụ 0.8nM na MAGL, na 3.0nM na FAAH. Mgbochi nke enzymes abụọ a na - akpata mmụba nke anandamide na 2-AG na ụbụrụ, na - ebute nsonaazụ Cannabinoid na ụdị omume omume cannabinoid na ọmụmụ anụmanụ, ebe enweghị ike ya na AChE pụtara na ọ nweghị ihe mgbaàmà cholinergic na-emepụta. ] [1] [2] [anọ] N'agbanyeghị usoro kemikal ya na ndị ọrụ ahụ amachibidoro iwu, ogologo ogologo alkyl nke IDFP na-eme ka ọ daa na mpụga nkọwa nke "kemịkal na-egbu egbu" n'okpuru Mgbakọ Ngwá Agha Chemical, njikọ organophosphorus metụtara, IDFP adịghị n'okpuru otu njikwa iwu siri ike.

 

Kedu ihe nyocha nke IDFP

Maka nchekwa ogologo oge, anyị na-atụ aro na IDFP ga-echekwa dị ka enye na -20 ℃. Ọ ghaghị ịdịgide ma ọ dịkarịa ala otu afọ.
A na-enye IDFP ka ọ bụrụ ngwọta na methyl acetate. Iji gbanwee ihe mgbaze ahụ, kpochasịa methyl acetate n'okpuru mmiri dị nwayọọ nke nitrogen ma gbakwunye ihe nkwụsị nke ndị na - ahọrọ. Ndị na - emepụta ihe dịka ethanol, DMSO, na dimethyl formamide nwere ike iji gas jupụtara. Solubility nke IDFP na ihe mgbaze ndị a bụ ihe dịka 10mg / ml.
Ọ bụrụ na achọrọ ọgwụ ngwọta maka nyocha nke ndụ, a ga-edozi ha kachasị mma site na ịmegharị ihe na-emepụta ihe n'ime ihe ndị na-edozi ahụ ma ọ bụ saline isotonic.Nọpụta na ihe ndị dị ndụ na-enweghị ihe ọ bụ, ebe ọ bụ na ihe ndị na-emepụta ihe nwere ike inwe mmetụta nrịanrịa na obere ihe. adighi akwado itinye ihe ngwọta nke otutu ihe kariri otu ubochi.

 

Otú IDFP si arụ ọrụ

IDFP bụ onye inhibitor nke na-apụghị ịgbagha agbagha maka ọtụtụ enzymes dị iche iche nke na-emekarị ka ọ ghara ịkụda ndị na-ahụ maka ntanetrị, ọ bụ ezie na ụdị IDFP dị ogologo na-eme ka ọ ghara ịdị ike dị ka onye na-emechi acetylcholinesterase (AChE), ebe ọ bụ onye na-egbochi enzymes abụọ monoacylglycerol lipase ( MAGL), bụ isi na enzyme nke na-eme ka 2-arachidonoylglycerol endocannabinoid (2-AG), na fatty acid amide hydrolase (FAAH), bụ isi nke enzyme nke na-eme ka ihe ndị ọzọ na-eme ka ọ bụrụ isi. Otu akụkụ organophosphorus nke na-ejikarị aka MAGL na FAAH na XXUMX na 50 nM, respectively.0.8 Na 3 mg / kg, IDFP na-ebuli ụbụrụ nke 1-AG na AEA karịa 10, ma belata ọkwa nke arachidonic acid site 2-n'ogige atụrụ.

 

Ịdọ aka ná ntị

Ngwaahịa a abụghị maka mmadụ ma ọ bụ ọgwụ ogwu, ịdọ aka ná ntị ọzọ ka na-eme nchọpụta. Zere iso gị na akpụkpọ anụ, anya, akụkụ iku ume, nsogbu ọ bụla, kpọọ dọkịta gị ozugbo.

 

IDFP (615250-02-7) Ntụ ntụ

Min iji 10grams.
Ajuju ajuju nke di n'ogo (N'ime 1kg) nwere ike iziputa na 12 awa mgbe ugwo.
Enwere ike iziga usoro ka ukwuu na 3 ụbọchị ọrụ mgbe ịkwụ ụgwọ.

IDFP Marketing

A ga-enye ha n'ọdịnihu na-abịa.

 

IDFP enwere mmetụta ọ bụla

A na-atụle ọgwụ dị nro na nnu na mmiri na nchịkwa ọbara na-adịte aka, nke a na - eme ka ọ bụrụ nke a na - eme ka ọ bụrụ nke a na - eme ka ọ dịkwuo afọ abụọ, ya bụ, cyclooxygenase-2 (COX-2) na fatty acid amide hydrolase (FAAH) . Ngwunye nke anandamide (15, 30, na 60 nmol · min-1 · kg-1) n'ime mkpịsị aka nke C57BL / 6J bụ ụmụ anụmanụ kpaliri diuresis na nnu nnu na COX-2- ma ọ bụghị usoro COX-1. Iji chọpụta ma endocannabinoids endogenous dị na medal medal nwere ike imepụta mmetụta yiri nke ahụ, mmetụta nke isramopodolic dodecyl fluorophosphate (IDFP), nke na-egbochi isi abụọ endocannabinoid hydrolases, a mụrụ. Ngwọta IDFP mere ka ọnụọgụ mmụm nke mmiri na sodium excretion na COX-2- mana ọ bụghị ụdị ego COX-1. Ejighị njehie ma ọ bụ IDFP emetụtare ọnụ ọgụgụ ntinye ntanetị. Ọ bụghị usoro mkpụrụ ndụ (0.625 mg · kg-1 · 30 min-1 iv) ma ọ bụ intramedullary (15 nmol · min-1 · kg-1 · 30 min-1) mmepe nke IDFP n'ihu anandamide intramedullary (15-30 nmol · min-1 · kg-1) nke na-eme ka a ghara ikpuchi ya, nke na-atụ aro na hydrolysis nke anandamide adịghị mkpa maka mmetụta ya diuretic. Ngwunye IDFP na-ejideghị ihe ọ bụla na-emetụta ọbara ọbara ma ọ bụ na-eme ka ọkpụkpụ ọbara na-agbanye mgbatị. Mmetụta nke IDFP maka mmụba nke mmamịrị na ọbara ọbara na-atụgharị uche bụ FAAH na-adabere dị ka egosipụtara na-eji FAAH knockout ụmụ oke. Nyocha nke urery PGE2 concentrations by HPLC-electrospray ionization massem spectrometry gosiri na ọgwụ NJFP belata urinary PGE2 Ihe ndị a na-adabere na ọrụ nke FAAH na endogenous anandamide-eme site na a COX-2-dependent metabolite iji mezie diuresis na nnu excretion na mousekidney.

 


 

Esi zụta IDFP ntụ ntụ (615250-02-7) site na AASraw

 

1.To kpọtụrụ anyị site na email anyị usoro nyocha, ma ọ bụ online skypeonye na-ahụ maka ndị ahịa (CSR).
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4.Bayment done and the goods will be sent out na 12 awa (N'ihi na iwu n'ime 10kg).
5.Goods natara ma kwuo ihe.