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10 110417 (88-4-XNUMX) Dolastatin

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SKU: 110417-88-4. Category:

AASraw nwere ikikere na mmepụta ikike site na gram ka usoro nchịkọta nke Dolastatin 10 (CAS 110417-88-4), n'okpuru usoro CGMP na usoro nchịkwa mma.

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Product Description

Dọkụl 10 Dolastatin


I.Danostatin 10 isi agwa:

aha: Dolastatin 10
CAS: 110417-88-4
Molekụla Formula: C42H68N6O6S
Ọbara arọ: 785.09G / mol
Melt Point: 94-95oC
Nchekwa Nche: Na-echekwa na ebe dị jụụ na akọrọ na 0 - 4 ℃ maka obere oge (ụbọchị ka izu) ma ọ bụ -57 ℃ maka ogologo oge (ọnwa ruo afọ)
agba: White na-acha ọcha ọcha


II. Diana 10 (110417-88-4) Dolastatin iji mee ihe na antitumor cycle

1. Aha:

Aha aha:
Dolastatin 10 (CAS 110417-88-4), Dolastatin-10, Neuro_000215, CCRIS 7310, CID100208, NSC376128,NSC 376128, C11280, L-Valinamide, N,N-dimethyl-L-valyl-N-(2-methoxy-4-(2-(1-methoxy-2-methyl-3-oxo-3-((2-phenyl-1-(2-thiazolyl)ethyl)amino)propyl)-1-pyrrolidinyl)-1-(1-methylpropyl)-4-oxobutyl)-N-methyl-, (2S-(1(1R*(R*),2S*),2R*(1S*,2S*,3(R*))))-

2.Dolastatin 10 eji:

Nzube: Ọkà mmụta sayensị sayensị nyochachara nrụpụta ọrụ na ọgwụ na-egbu egbu nke omekorita microtubule dị iche iche na-eme dolastatin-10 na ndị ọrịa na-arịa ọrịa ara.

Ụzọ: Ndị ọrịa iri abụọ na otu na-arịa ọrịa cancer metastatic nwere ọgwụgwọ na-eme dolastatin-10 na ọgwụ 400 mcg / m2 site na bolus na-abanye n'ime oge ọ bụla na 3 izu.

Nsonaazụ: Otu n'ime ndị ọrịa 21 (5%; 95% CI: 0-24%) rụpụtara remission maka oge 113. Ndị ọrịa anọ nọ na-enwe ọrịa na-ebute ọrịa maka oge nke 87 ụbọchị. Ndị ọrịa natara nkeji abụọ nke dolastatin-10. Ọrịa hematologic dị njọ, na ọrịa 8 na-emepụta 4 neutropenia, na 5 na 3 neutropenia; a hụrụ 3 febrile neutropenia. Usoro nhazi nke 3 na 4 neutropenia enwere na 36% nke usoro ihe omume. Ọrịa na-adịghị na hematologic bụ ihe a na-adịghị ahụkebe.

Nchikota: Ọ bụ ezie na a nabatara proactive toxicity of the dolastatin-10, o nwere ntakịrị ihe n'ime nchọpụta ọrịa cancer ara ọganihu a.

Na Vitro: Dolastatin 10 bụ pentapeptide pụrụ iche nke dịpụrụ adịpụ na Dolabella auricularia. A chọpụtara na data ndị a na vitio na-adị nnọọ ka nke Dolastatin 10 na PEA Auristatin, nke ọ bụla nwere ihe GI50 nke 10-5-10-6 μg / mL (10-2-10-3 nM) megide otu minipanel nke mkpụrụ ndụ mmadụ. Njikọ ọgwụ na-emegide ọgwụ (ADC) gụnyere antibody CD30 monoclonal cAC10 conjugated to the agent cytotoxic agent monomethyl auristatin E (MMAE), otu analogic synthetic nke tubing polymerization inhibitor Dolastatin 10 (110417-88-4).

3.Warning na Dolastatin 10

Ngwaahịa a bụ maka nyocha, ọ bụghị maka mmadụ ma ọ bụ ọgwụ ogwu.

Maka inweta elu solubility, biko kpoo ọkụ na 37 ℃ na ikwanye ya na ultrasonic bat maka a while.Stock ngwọta nwere ike ịchekwa n'okpuru -20 ℃ maka ọtụtụ ọnwa.

4.Further ntụziaka:

Ngwunye 10 Dolastatin
Ejiri usoro 10 (110417-88-4) Dolastatin zuru ezu site n'inwe mmepụta nke ọma nke abuo amino acid isi, Dil (6) na Dap (11), na njikọta ụkwụ nke ise amino acid site na C-terminal Doe .

Njikọ na Nyocha nke Dolanatin 10 Analogues nwere Heteroatoms na Amino Acid Side Chains.
Ihe ntụgharị uche na-atụgharị uche nke ihe ndị na-eme bụ 10 dolastatin na-enwe mmasị dị ukwuu na ọrịa kansa n'ihi ọrụ ike ha dị n'ime vitro na ojiji ha dị ka ndị a na-ebute na ọgwụ mgbaba (ADCs). Mgbanwe nke scaffold 10 a na-eme doodine emetụtala ọtụtụ mgbanwe nke P1, N-terminus, na P5, C-terminus, na-elebara anya na P2.

Na nyocha nke cellular, Dolastatin 10 (110417-88-4) na-egosi ọrụ megide ụfọdụ arịa ọrịa leukemia mmadụ, lymphoma na mkpụrụ ndụ tumo siri ike (dịka OVCAR-3 na NSCLC) na IC50 si na 0.1nM gaa na 10nM. A na-anwale ya ugbu a n'ule ahụ.


III. 10 (110417-88-4) HCML Dolastatin

Anyị bụ ndị na-enweghị ntụsara ahụ, Preditting powder for sale, Raw Aprepitant powder (170729-80-3) hplc >98% | AASraw R & D Reagents


IV. Esi zụta Dolastatin 10 si AASraw?

1.To kpọtụrụ anyị site na email anyị usoro nyocha, ma ọ bụ skypeonye na-ahụ maka ndị ahịa (CSR).
2.To nye anyị ọnụọgụgụ na adreesị gị.
3.OUR CSR ga-enye gị nkọwa, okwu nkwụ ụgwọ, nọmba nchịkọta, ụzọ nnyefe na ụbọchị mbata echere (ETA).
4.Bayment done and the goods will be sent out na 12 awa (N'ihi na iwu n'ime 10kg).
5.Goods natara ma kwuo ihe.


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