Alfaxalone (23930-19-0) ntụ ntụ - Onye na-emepụta ihe nrụpụta
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Alfaxalone

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Alfaxalone bụ ihe na-adịghị ahụ anya nke na-eme ka steroid na-emetụta ihe na-emepụta ihe. A kọwara Alfaxalone nke ọma dị ka 3-α-hydroxy-5-α-pregnane-11, 20-dione, ma nwee ogo dị arọ 332.5…

Product Description

Njirimara Nhazi

Product Name Alfaxalone
CAS Number 23930-19-0
molekụla Formula C21H32O3
Ụdị Ụdị 332.48
Synonyms Alfalone;

Alfaxalone;

23930-19-0;

5alpha-afọ ime-3alpha-ol-11,20-dione;

Alfaxalonum.

ọdịdị White ntụ ntụ
Nchekwa na Ijikwa Chekwaa na ime ụlọ a na-achịkwa -20 Celsius

 

Nkọwa Alfaxalone

Alfaxalone bụ ihe na-adịghị ahụ anya nke na-eme ka steroid na-emetụta ihe na-emepụta ihe. A kọwara Alfaxalone nke ọma dịka 3-α-hydroxy-5-α-pregnane-11, 20-dione, ma nwee ogo molekụle 332.5. Usoro bụ isi maka ihe nhụjuanya nke alfaxalone bụ mgbanwe nke ntanetị nke membrane chloride ion, nke a na-ebute site na njikọ nke alfaxalone na GABAA (gamma-aminobutyric acid) ndị nabatara sel.

 

Alfaxalone usoro ihe

Alfaxalone na-emepụta amamịghe site na ịme ihe gamma aminobutyric acid subtype A (GABAA) ndị natara na sistemụ ụjọ nke etiti (CNS). Ndị nabatara ndị a bụ ọwa ndị nwere njikọ ionotropic, na GABA bụ njikọ ha dị egwu. GABA bụ isi ihe na-egbochi neurotransmitter na CNS. Mgbe emeghachitere onye na-anabata ihe, ọwa ahụ meghere ma kwalite nkwanye chloride n'ime sel ahụ, na-eme ka hyperpolarization nke akpụkpọ ahụ postynaptik. N'ebe dị ala, alfaxalone na-agbanwezi chloride nke ọma site na ọwa chloride; ma na elu kasịnụ, ọ na-arụ ọrụ dị ka GABA agonist, n'otu ụzọ ahụ dị ka barbiturates. Nsonaazụ njedebe bụ ịgba ụra miri emi ma ọ bụ ntinye nke anesthesia, dabere na ọgwụ na ụzọ nchịkwa.

 

Ngwa Alfaxalone

Alfaxalone, nke a makwaara dị ka alphaxolone ma ọ bụ alphaxalone ma jiri ya mee ihe n'ahịa aha ya bụ Alfaxan, bụ steroid na-adịghị arụ ọrụ na ọgwụ na-akụnwụ ahụ na-ejikarị nkịta na nwamba. Enwere ike iji ya dị ka onye na-emepụta ihe na-emepụta ihe ma ọ bụ maka nhụjuanya izugbe.

 

Alfaxalone Uru & ụkọ ihe ụfọdụ

  • uru:

Alfaxalone na-akpata ntakịrị mgbanwe na mmepụta obi ma ọ bụ ọbara mgbali elu mgbe a na-enye ndị ọrịa ahụike dị mma. Alfaxalone nwere ndekota ọgwụgwọ dị elu, ọ na-eme obere oge, na-anaghịkwa ede akwụkwọ. Njirimara ndị a na-eme ka alfaxalone dị mma maka iji ya dị ka onye na-ebute ihe na-emepụta ma ọ bụ maka ịnye ọgwụ nhụjuanya.

Alfaxalone nwekwara ike ịnye intramuscularly, ya mere enwere ike iji ya mee ka ndị ọrịa kwenyeghị. Mgbe a na - eji alfaxalone mee ka onye ọrịa nwee ike ịgwọ ọrịa ahụ bụ 1-3mg / kg IM ma ọ na - ejikarị opioid eme ihe maka ezigbo izu ike.

Mgbe ejiri alfaxalone maka caesarean ngalaba ụmụ nkịta na-amụ anya ma na-adị ndụ na mmụba AGPAR ka mma ma e jiri ya tụnyere propofol.

 

  • ọghọm:

Alfaxalone na-akpata nkụda mmụọ na-adabere n'ịda mbà n'obi, na-enwe ike ịme ọrịa na-esochi ngwa ngwa ngwa ngwa. Dịrị njikere ịmalite, nye nkwado oxygen, na ikuku mgbe ị na-eji alfaxalone maka ntinye ma ọ bụ nkwụsị.

Nchịkwa gabigara ókè nke alfaxalone nwere ike ibute ịda mbà n'obi nke mkpụrụ ọgwụ, yana mbelata dị ukwuu na mmepụta obi na ọbara mgbali. Uzo ogwu alfaxalone kwesiri ka eji nlezianya kpoo ya na ndi oria nke belatalata obi ma obu enweghi ike hemodynamically.

Alfaxalone adịghị enye analgesia ọ bụla, ya mere a ga-eji ya na opioid kwesịrị ekwesị maka usoro mgbu.

Mgbe etinyere alfaxalone intramuscularly olu nke ntụtụ nwere ike buru ibu, nwere ike ịkpata mgbu na ntụtụ. Nnukwu olu ahụ nwekwara ike ime ka nchịkwa nchịkwa bụrụ ihe ịma aka mgbe enwere windo nwere oke maka ogwu ogbugba n'ihi ọnọdụ ndidi. Ọchịchị Alfaxalone nwere ike ime ka ọ ghara ịdapụta na-agbake site na ogo dị iche iche, olu olu, na / ma ọ bụ myoclonus.

 

Reference

[1] Whittem T, Pasloske KS, Heit MV et al. Ndị ọzọ (2008) Ọgwụ pharmacokinetics na pharmacodynamics nke alfaxalone na nwamba mgbe otu na otutu intravenous ochichi nke Alfaxan na-adakarị na supraclinical doses. J Vet Pharmacol Ther 31 (6), 571-579.

[2] Ferre PJ, Pasloske K, Whittem T et al. Ndị ọzọ (2006) Plasma pharmacokinetics nke alfaxalone na nkịta mgbe eriri afọ nke Alfaxan-CD. Vet Anaesth Analg 33, 229-236.

[3] Muir W, Lerche P, Wiese A et al. Ọgwụgwọ (2009) Mmetụta obi na anesthetic nke usoro ọgwụgwọ na supraclinical nke alfaxalone na nwamba. Anyi Anaesth Analg 36, 42-54.

[4] Clarke KW, Kpaa CM, Halllọ Nzukọ LW, eds. (2014). "Isi 15: Anesthesia nke nkịta". Anesthesia ọgwụgwọ ọrịa anụmanụ (11th ed.). Oxford: WB Saunders. peeji nke 135-153.

[5] Varga M (2014). "Isi nke 4: Anesthesia and Analgesia". Akwụkwọ ọgụgụ nke Rabbit Medicine (2nd ed.). Butterworth-Heinemann. peeji nke 178-202.

[6] Nieuwendijk H (Machị 2011). "Alfaxalone". Ahụhụ Anesthesia & Analgesia Support Group. Weghachite na July 14, 2017.

[7] Zeltzman P (November 17, 2014). "Ihe kpatara ịhazi Alfaxalone Ji Chọọ Otu Nkụzi". Veterinary Practice Akụkọ. Weghachite na July 14, 2017.