(CAS 681136-29-8) N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamide ntụ ntụ | AASRAW
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N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide

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N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide video

 

 


 

N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide basic Characters

 

aha: N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
CAS: 681136-29-8
Ịdị ọcha: ≥99% (HPLC)
Synonyms: JNJ 1661010;N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide;Takeda-25;1-Piperazinecarboxamide, N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-;JNJ 1661010, >=98%
Usoro Molecular: C19H19N5OS
Molekụla arọ: 365.459
Ebe na-agbaze: 240.48
Isi okwu: 559.69 Celsius C na 760 mmHg
njupụta: ~ 1.3 g / cm3
Nchekwa Nche: Na-echekwa na + 4 Celsius C
Solubility: DMSO: ≥28mg / mL
Ntughari ihe omuma: N20D 1.68
agba: A crystalline siri ike
InChI: InChI=1S/C19H19N5OS/c25-18(20-16-9-5-2-6-10-16)23-11-13-24(14-12-23)19-21-17(22-26-19)15-7-3-1-4-8-15/h1-10H,11-14H2,(H,20,25)
KeyInChI: BHBOSTKQCZEAJM-UHFFFAOYSA-N

 


 

N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid Utu ojiji na uzo

aha

N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid ntụ ntụ, JNJ 166101 ntụ ntụ

Kedu ka ọrụ si N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid Powder use

FAAH nọ na JNJ-1661010 na-atụ aro ngwa ngwa nke mkparịta ụka dị n'etiti JNJ1661010 na saịtị na-arụ ọrụ, nke a na-emewanye na okpomọkụ dị elu. JNJ-1661010 bụ onye na-arụ ọrụ na-arụ ọrụ, dịka nyochaa site na LC-ESI-MS. Ngwurugwu JNJ-1661010 na phenylthiadiazole na ọdọ mmiri hydrophobic na phenylurea dị na akpa hydrophilic nke FAAH, JNJ-1661010 (20 mg / kg ip) na-egbochi FAAH site ma ọ dịkarịa ala 85% maka ruo 4 h mgbe dosing, nchịkọta nke egbugbere ọnụ ethanolamides na ụbụrụ ụbụrụ. Ngwunye JNJ-1661010-na-adabere n'ụzọ dị irè iji chepụta allodynia nke kachasị rụọ ọrụ nke 90% na 30 min kwadoro na Mild Thermal Result (MTI) ụmụ oke na oke oke. JNJ-1661010 (20 mg / kg) na-agbanwe agbanwe site na 60.8% na 30 min na ụbụrụ na-agwọ ọrịa na-egbu egbu. JNJ-1661010 (50 mg / kg ip) na-egosi nrịtapụta dị ịrịba ama nke hyperalgesia na 30 min kwadoro na ụdị carrageenan rat na-egbu mgbu.
Rats na JNJ-1661010 (20 mg / kg ip) nwere Cmax nke 26.9 μM plasma na Tmax nke 0.75 h na Cmax na ụbụrụ nke 6.04 μM na Tmax nke 2 h. JNJ-1661010 (20 mg / kg ip) na - egbochi ụbụrụ FAAH ma bulie AEA larịị na ụbụrụ ụbụrụ na oke.

Ntuziaka ọzọ

N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamid Powder

Min iji 10grams.
Ajuju ajuju nke di n'ogo (N'ime 1kg) nwere ike iziputa na 12 awa mgbe ugwo.
Maka usoro ka ukwuu (N'ime 1kg) nwere ike zipụ na 3 ụbọchị ọrụ mgbe ịkwụ ụgwọ.

N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamid powder Marketing

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