Njirimara Nhazi

Product Name	Nicotinamide riboside chloride
CAS Number	23111-00-4
molekụla Formula	C11H15ClN2O5
Ụdị Ụdị	290.7
Synonyms	23111-00-4 Nicotinamide riboside chloride Nicotinamide riboside (chloride) 3-Carbamoyl-1-((2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride Nicotinamide ribose chloride
ọdịdị	White ntụ ntụ
Nchekwa na Ijikwa	0 - 4 C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 C maka ogologo oge (ọnwa).

 

Nicotinamide riboside chloride Nkọwa

Nicotinamide Riboside Chloride (NIAGEN) bụ ụdị nnu nke chloride nke nicotinamide riboside (NR) .NR bụ ụdị pyridine-nucleoside nke vitamin B3 nke na-arụ ọrụ dị ka ihe na-ebute nicotinamide adenine dinucleotide (NAD) ma ọ bụ NAD + .NIAGEN na-ahụkarị dị mma (GRAS) dị na United States maka iji ngwaahịa nri. Nicotinamide riboside chloride bụ kristal ụdị Nicotinamide riboside (NR) chloride. Nicotinamide riboside chloride na-abawanye ọkwa NAD [+] ma na-eme ka SIRT1 na SIRT3 rụọ ọrụ, na-ejedebe na nkwalite metabolism na nchedo ya na abụba abụba na-ebute ihe na-emetụta ụbụrụ. Nicotinamide riboside chloride ntụ ntụ na-eji na mgbakwunye nri.

 

Nicotinamide riboside chloride Mechanism nke Action

Nicotinamide Riboside Chloride (NIAGEN) bụ ụdị nnu nke chloride nke nicotinamide riboside (NR). NR bụ ụdị pyridine-nucleoside nke vitamin B3 nke na-arụ ọrụ dị ka ihe bu ihe mbu nke nicotinamide adenine dinucleotide ma ọ bụ NAD +. NR na-egbochi mmebi nke ịwa ahụ mgbatị ganglion neurons ex vivo ma na-echebe megide mkpọtụ na-akpata ịnụ ntị na ụmụ oke. Nicotinamide riboside ntụ ntụ na-egbochi ahụ ike, ụbụrụ na melanocyte stem cell senescence. Achọpụtala mmụba nke muscular na ụmụ oke mgbe ọgwụgwọ na nicotinamide riboside, na-eduga na ịkọ nkọ na ọ nwere ike melite nchịkwa nke akụkụ ndị dị ka imeju, akụrụ, na obi. Nicotinamide riboside na-ebelata glucose ọbara na imeju araba na prediabetic na ụdị ụdị ọrịa shuga 2 ma na-egbochi mmepe nke ọrịa neuropathy nke ọrịa shuga. Mara: Nicotinamide Riboside chloride bụ ngwakọta α / β.

 

Nicotinamide riboside chloride Ngwa

Nicotinamide riboside chloride ntụ ntụ ka e debara aha ya na nọmba CAS 23111‐00‐4 na EC nọmba 807‐820‐5. Aha ya IUPAC bụ 1 - [(2R, 3R, 4S, 5R) ‐3,4 ‐ dihydroxy ‐ 5‐ (hydroxymethyl) oxolan ‐ 2 ‐ yl] pyridin ‐ 1 ‐ ium ‐ 3 ‐ carboxamide; chloride. Thedị ihe omimi nke nicotinamide riboside chloride bụ C11H15N2O5Cl, na 290.7 g / mol. Nicotinamide Riboside Chloride (NIAGEN) bụ ụdị nnu nke chloride nke nicotinamide riboside (NR) .NR bụ ụdị pyridine-nucleoside nke vitamin B3 nke na-arụ ọrụ dị ka ihe butere nicotinamide adenine dinucleotide (NAD) ma ọ bụ NAD +. Ahụ chọrọ NAD + iji rụọ ọrụ nke ọma. Obere NAD + nwere ike ibute nsogbu ahụike. Iwere nicotinamide riboside nwere ike inye aka bulie ọkwa NAD + ndị a dị ala.

 

uru nke Nicotinamide riboside chloride

Nicotinamide riboside Chloride, NAD + nke na-arụ ọrụ nke ọma, na-abawanye ọkwa NAD + ma rụọ ọrụ SIRT1 na SIRT3. Nicotinamide riboside Chloride ntụ ntụ bụ isi iyi nke vitamin B3 (niacin) ma jiri Nicotinamide riboside Chloride ntụ ntụ nwere ike ịkwalite metabolism oxidative, na-echebe ya pụọ ​​na nri abụba dị ukwuu na-ebute ihe na-emetụta ụbụrụ. Nicotinamide riboside Chloride na-ebelata mmetụ nke na-arịa ọrịa Alzheimer.

 

Reference

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[2] Bogan KL, Brenner C. Nicotinic acid, nicotinamide, na nicotinamide riboside: nyocha nyocha mkpụrụ ndụ nke NAD + preursor vitamin na nri mmadụ. Annu Rev Nutr. 2008; 28: 115-30. ma ọ bụ: 10.1146 / annurev.nutr.28.061807.155443. Nyocha. PubMed PMID: 18429699.

[3] Ghanta S, Grossmann RE, Brenner C. Mitochondrial protein acetylation dị ka cell-intrinsic, evolutionary driver of abụba nchekwa: kemịkal na usoro mgbagha nke mgbanwe acetyl-lysine. Crit Rev Biochem Mol Biol. 2013 Nov-Dec; 48 (6): 561-74. ma ọ bụ: 10.3109 / 10409238.2013.838204. Nyocha. PubMed PMID: 24050258; PubMed Central PMCID: PMC4113336.

[4] Yang Y, Sauve AA. NAD (+) metabolism: Bioenergetics, akara aka na nhazi maka ọgwụgwọ. Biochim Biophys Iwu. 2016 Mkpebi; 1864 (12): 1787-1800. ma ọ bụ: 10.1016 / j.bbapap.2016.06.014. Nyocha. PubMed PMID: 27374990.

[5] Sauve AA. NAD + na vitamin B3: site na metabolism na ọgwụgwọ. J Pharmacol Exp Ther. 2008 Mar; 324 (3): 883-93. ma ọ bụ: 10.1124 / jpet.107.120758. Nyocha. PubMed PMID: 18165311.

[6] Kato M, Lin SJ. Iwu nke NAD + metabolism, na-egosi ihe na itinye aka na ya na yist Saccharomyces cerevisiae. Mmezi DNA (Ihe). 2014 Nov; 23: 49-58. ma ọ bụ: 10.1016 / j.dnarep.2014.07.009. Nyocha. PMID PubMed: 25096760; PubMed Central PMCID: PMC4254062.

[7] Cantó C, et al. NAD (+) precoror nicotinamide riboside na-eme ka metabolism dị ike ma na-echebe ihe na-edozi oke abụba. Cell Metab. 2012 Jun 6; 15 (6): 838-47.

[8] Bing Gong, et al. Nicotinamide Riboside na-eweghachi Cognition Site na Nkọwapụta nke Onye Na-anabata Ihe Nlekọta-γ Coactivator 1α Iwu β-Secretase 1 Degradation na Mitochondrial Gene Expression na Alzheimer's Mouse Models. Neurobiol ingka nká. 2013 Jun; 34 (6): 1581-8.

[9] Collin D Heer, et al. Coronavirus na PARP Expression Dysregulate the NAD Metabolome: Akụkụ nwere ike ịrụ ọrụ nke enweghị nsogbu. mmmmmmmmmmmm 2020 Apr 30; 2020.04.17.047480.

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