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17-Hydroxyprogesterone na-ekpuchi ntụ ntụ

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AASraw nwere ikikere na mmepụta site na gram ka usoro nchịkọta nke 17-Hydroxyprogesterone na-acha uhie uhie (630-56-8), n'okpuru usoro CGMP na usoro nchịkọta mma.

17-Hydroxyprogesterone na-ekpuchi ntụ ntụ, Ihe fọrọ nke nta ka ọ bụrụ ụmụaka 500,000 mụrụ na mbụ na United States kwa afọ. Ọmụmụ ime nwa (PTB), ma ọ bụ ịmụ nwa karịa nkedo nke 37, na-etinye ụmụ ọhụrụ n'ọnọdụ ize ndụ dị elu nke ọnwụ ma bụrụ isi ihe kpatara ọrịa nkwarụ na-adịru nwa oge na ụmụaka. Tụkwasị na nke ahụ, ụgwọ ọrụ ahụike PTB metụtara ụlọ ọrụ nlekọta ahụ ike nke US karịa $ 26 kwa afọ. Ime ka PTB dị oké mkpa iji mee ka ahụike na mmepe nke ụmụ ọhụrụ gafee mba ahụ.

Product Description

17-Hydroxyprogesterone na-ekpo ọkụ ntụ ntụ


I.17-Hydroxyprogesterone na-eme ka ntụ ntụ na-emepụta ihe dị iche iche:

aha: 17-Hydroxyprogesterone na-ekpuchi ntụ ntụ
CAS: 630-56-8
Molekụla Formula: C27H40O4
Ọbara arọ: 428.6
Melt Point: 119 ° C
Nchekwa Nche: Ụlọ okpomọkụ
agba: White na-acha ọcha ntụ ntụ


II. 17-Hydroxyprogesterone na-ekpuchi ntụ ntụ

1. Aha:

Aha Mmiri: 17-Hydroxyprogesterone uzuzu ahihia
Aha ndị ọzọ: 17-OHPC, 17P, hexanoate

2. 17-Hydroxyprogesterone okpuru uzuzu Uzo:

Ngwá ọgwụ 17-alpha hydroxyprogesterone ọgwụ bụ progestin injectable prophyin. E gosipụtara na ọ dị irè iji gbochie ma ọ bụ na-egbu oge ịmalite ịmụ nwa n'ime ime ụmụ nwanyị nwere akụkọ banyere ịmalite ịmụ nwa .1 Ozugbo a na - enweta ya dị ka ọgwụ dị oke ọnụ, ọ nwere ugbu a ụdị (Makena; AMAG Pharmaceuticals) nke na - efu 100 ugboro karịa ihe mbụ. Na February 4, 2011, KV Pharmaceutical Company (nke e mesịrị renamed Lumara) natara nkwado site na US Food and Drug Administration iji rụpụta ma na-ere ahịa Makena, nke a na-agụnye otu ihe ahụ na-arụsi ọrụ ike dị ka ọ dị na mbụ. Nkwekorita a gụnyere inye ụmụ nwanyị ọgwụ ọjọọ ma nye KV Pharmaceutical Company ikike naanị maka imepụta Makena, nke nwere ike inye aka na ọnụahịa elu ya. Maka ọmụmụ ihe a, anyị ji nchekwa data ịchọrọ ịchọta ihe ndenye ọgwụ maka 17-alpha hydroxyprogesterone nke dị n'etiti ndị na-azụ ahịa 4000 (ọ bụghị Medicaid) ụmụ nwanyị dị ime. Ebumnuche anyị bụ ịghọta ihe eji, ụgwọ, na ihe ndị sitere na nsụgharị ọgwụ ndị a na-emepụta na nke a na-agbakwụnye.

3.What bụ usoro onu ogwu nke 17-Hydroxyprogesterone?

250 mg otu ugboro kwa izu (ụbọchị 7 niile); malite usoro ọgwụ n'etiti izu 16, ụbọchị 0 na izu 20, 6 ụbọchị gestation; gaa n'ihu ruo izu 37 (site na izu 36, 6 ụbọchị) nke ịmegharị ma ọ bụ nnyefe, ebe ọ bụla na-ebu ụzọ.

Anyị na-eduzi nnwale abụọ gbara anya, nke a na-ahụ maka ebe a na - achịkwa ụmụ nwanyị dị ime na - edekọ akụkọ ihe mere eme nke nnyefe a na - ebuteghị. A debanyere ụmụ nwanyị na 19 ụlọ ọgwụ na 16 ruo 20 izu nke gestation na enweghị mgbakọ site na central data center, na 2: 1 ruru, iji nweta ma ọ bụ izu injections nke 250 mg nke 17P ma ọ bụ izu injections nke inert oil placebo; a nọgidere na-aga n'ihu ruo mgbe a ga-enyefe ma ọ bụ na 36 izu nke gestation. Ihe kachasị pụta bụ ịnyefe tupu oge 37 nke gestation. A na-eme nchọpụta dịka ụkpụrụ nke ebumnuche.

Ebumnuche akara ala nke ụmụ nwanyị 310 nọ na progesterone na ụmụ nwanyị 153 nọ na placebo bụ otu. Ọgwụgwọ na 17P budata belata ohere nke nnyefe na ihe na-erughị ụbọchị 37 nke nkedo (ọnọdụ, 36.3 pasent dị na otu onye na-ahụ maka mgbatị na vs. 54.9 pasent na mpaghara placebo, nsogbu dị ize ndụ, 0.66 [95 percent interval, 0.54 to 0.81]), ezigara na ntinye oge 35 na njigide (ihe kpatara, 20.6 percent vs. 30.7 percent, ihe ize ndụ metụtara, 0.67 [95 percent oge obi ike, 0.48 ka 0.93]), na nnyefe na obere oge 32 gestation (11.4 percent vs. 19.6 percent ; ihe ize ndụ, 0.58 [95 percent oge obi ike, 0.37 ka 0.91]). Ụmụaka nke ụmụ nwanyị na-emeso 17P nwere ọtụtụ ọnụọgụ nke necrotizing enterocolitis, hemorrhage intraventricular, na mkpa maka oxygen ọzọ.

Njere nke 17P kwa izu mere ka ọnụ ọgụgụ dị ukwuu nke nnyefe na-ebute oge na-aga n'ihu n'etiti ndị inyom bụ ndị nwere nnukwu ihe ize ndụ maka ịbịanye aka na mbu ma belata ọtụtụ nsogbu na ụmụ ha.

4.How Cortexolone 17-Hydroxyprogesterone na-arụ ọrụ ntụpọ?

17a-hydroxyprogesterone caproate (17-OHPC) bụ progestogen synthetic. Ahụ mmadụ anaghị eme ka ihe ahụ dị na ya. Aha ọzọ a na-akpọ "hexanoate," bụ onye ester sitere na hexanoic (ma ọ bụ caproic) acid. Usoro nke 17-OHPC gosipụtara na Ọgụgụ. Ụfọdụ ndị dọkịta kwuru na 17-OHPC dị na ewu. Nke a yiri ka ọ bụ omenala, n'ihi na njirimara nke mole mole a sitere n'anụ ahụ, anụ ahụ si ewu, ma ọ bụ ihe ọ bụla ọzọ dị ndụ nwere ike ghara ikwenye na nyocha akwụkwọ.

Mmetụta nke 17-OHPC na ogologo oge nke ndị ọrịa nwere akụkọ ihe mere eme nke ≥ 1 ọmụmụ ọmụmụ mbụ ndị e kenyere iji nweta 17-OHPC na otu ngalaba na-adịghị edozi. Enweghị ihe dị iche na ogologo oge na-emekarị ka ọ dịkwuo oge n'oge ndị inyom natara 17-OHPC. N'ụzọ dị iche, progesterone na-eme ka mmiri ghara ịdị na-eme ka ọnụ ọgụgụ nke ndị na-arịa ọrịa na-eme ka mkpịsị ụkwụ na-adị mkpụmkpụ na ndị ọrịa nwere akụkọ ihe mere eme nke ọmụmụ tupu oge ebido ma ọ bụ na-eme mkpụmkpụ.

17 alpha-hydroxyprogesterone caproate (17P) bụ ụdị mmepụta nke progesterone nke egosipụtara iji belata nlọghachi nke PTB maka ndị inyom na-enwe abụ ọchị nke nwere akụkọ ihe mere eme nke gara aga. Ụmụ nwanyị nwere akụkọ ihe mere eme nke PTB ga-enwe ike ịmalite nwa ọhụrụ tupu e jiri ya tụnyere ndị inyom. Ndị dọkịta na-edekarị, 17P na-eduzi site na injections kwa izu na-amalite na 16-24 izu ruo mgbe ị ga-ebute. Nnyocha na-egosi na inye 17P otu nwanyị ruru eru na-ebelata ohere nke inwe PTB ọzọ site na 33 pasent. Kwa afọ, ihe dịkarịrị, ụmụ nwanyị dị ime 30,000 ruru eru ma bụrụ ndị a na-ewere dị ka ndị ruru eru maka 17P.

5.Warning:

Mbelata ihe ize ndụ nke ịmalite ịmụ nwa na ụmụ nwanyị na-enwe ime nwa na-enwe akụkọ ihe mere eme nke singleton nke ọmụmụ nwa oge (a họpụtara ọgwụ FDA maka nwaazụ).

Mgbalị siri ike kpebisiri ike ịdabere na mmụba nke ụmụ nwanyị ndị napụtara na <37 izu nke gestation; ezigbo uru (dịka, mmụba nke nhụjuanya na ọnwụ) adịghị eguzobe.

Nchebe na nrụpụta ọrụ gosipụtara naanị n'ime ụmụ nwanyị nwere ọmụmụ nwa na-aga n'ihu; adighi ezubere ka o jiri ya mee ihe na ndi nwanyi nwere otutu ozo ma obu ihe ndi ozo di na ihe ize ndụ maka ime omumu.

ACOG na-atụ aro ịnye mgbakwunye progesterone maka mgbochi ịmalite ịmụ nwa na-ebuteghachi na ụmụ nwanyị nwere ime nwa na-agụ nwa ma ọ bụ ịmụ nwa tupu oge ọmụmụ <37 izu nke gestation n'ihi ọrụ mgbochi ma ọ bụ nkata na-emezughị.

6.17-Hydroxyprogesterone akpụkpọ ntụ ntụ:

Min iji 10grams.
Ajuju ajuju nke di n'ogo (N'ime 1kg) nwere ike iziputa na 12 awa mgbe ugwo.
Enwere ike iziga usoro ka ukwuu na 3 ụbọchị ọrụ mgbe ịkwụ ụgwọ.

7.17-Hydroxyprogesterone okpuru ntụ ntụ ntụ Ezi ntụziaka:

Ịjụ ajụjụ maka ndị na - anọchite anya anyị (CSR) maka nkọwa, maka amaokwu gị.

8.17-Hydroxyprogesterone okpueze ntụ ọka Marketing:

A ga-enye ha n'ọdịnihu na-abịa.

9.Does 17-Hydroxyprogesterone na-ekpuchi ntụ ntụ nwere ihe ọ bụla metụtara?

  • Synthetic progestin; emepụtara site na esterification nke 17α-hydroxyprogesterone, ihe na-emekarị nke metabolite nke progesterone, na acid caproic.
  • Enwere ọrụ progestogenic siri ike; egosi na ọ ga-emepụta mmetụta dị ukwuu na-adịgide adịgide ma dịkwuo ogologo karịa na progesterone.
  • O yiri ka enwere etrogenic, antiandrogenic, estrogenic, ma ọ bụ ọrụ glucocorticoid.

Ime ihe iji belata ihe ize ndụ nke ịmalite ịmụ nwa na-amaghị


III. 17-Hydroxyprogesterone na-ekpuchi ntụ ntụ HNMR

Anyị bụ ndị na-enweghị ntụsara ahụ, Preditting powder for sale, Raw Aprepitant powder (170729-80-3) hplc &gt;98% | AASraw R &amp; D Reagents


IV. Olee otú ịzụta 17-Hydroxyprogesterone na-ekpuchi ntụ ntụ si AASraw?

1.To kpọtụrụ anyị site na email anyị usoro nyocha, ma ọ bụ skypeonye na-ahụ maka ndị ahịa (CSR).
2.To nye anyị ọnụọgụgụ na adreesị gị.
3.OUR CSR ga-enye gị nkọwa, okwu nkwụ ụgwọ, nọmba nchịkọta, ụzọ nnyefe na ụbọchị mbata echere (ETA).
4.Bayment done and the goods will be sent out na 12 awa (N'ihi na iwu n'ime 10kg).
5.Goods natara ma kwuo ihe.


Chọpụta ihe kacha amasị gị:

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Nkowa gbasara ngwaahịa bara uru,Nabata ebe a.


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