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MMAD (10 Demethyldolastatin)

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SKU: 203849-91-6. Category:

AASraw nwere ikikere na mmepụta site na gram na usoro MMAD (Demethyldolastatin 10) (CAS 203849-91-6), n'okpuru usoro CGMP na usoro nchịkọta mma.

Ọzọkwa, MMAD ekwu na a ga-eji ya mee ihe na-emepụta ọgwụ ndị na-egbochi ndị na-agwọ ọrịa ọgwụ (NDCs). Na NDCs, MMAD jikọtara ya na antibody 5T4 ma ọ bụ mgbochi Her2. A na-egosi na ndị NDC gosipụtara nrụpụta dị mma na ọgwụcokinetics.

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MMAD (Demethyldolastatin 10) video


MMAD (Demethyldolastatin 10) isi ihe

aha: MMAD (10 Demethyldolastatin)
CAS: 203849-91-6
Molekụla Formula: C41H66N6O6S
Ọbara arọ: 771.06
Melt Point: N / A
Nchekwa Nche: Powder -20 ° C 3 afọ
4 Celsius C 2 afọ
Na ihe mgbaze -80 Celsius C 6 ọnwa
-20 ° C 1 ọnwa
agba: White na-acha ọcha (siri ike)


MMAD (10 Demethyldolastatin) (203849-91-6) iji mee ihe na steroid

aha

Synonyms: 10 Demethyldolastatin (203849-91-6); Monomethylauristatin D; Monomethyl Dolastatin 10
Chemical Name: (S)-N-((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(((S)-2-phenyl-1-(thiazol-2-yl)ethyl)amino)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide

Ịdọ aka ná ntị na MMAD (Demethyldolastatin 10)

Enwetaraghị ngwaahịa nke ọma maka ngwa ahụike. Maka nyocha ihe naanị

Maka inweta elu solubility, biko kpoo ọkụ na 37 ℃ na ikwanye ya na ultrasonic bat maka a while.Stock ngwọta nwere ike ịchekwa n'okpuru -20 ℃ maka ọtụtụ ọnwa.

Ntuziaka ọzọ

Na vitro: MMADUMX-10-203849) (91-6-2.0) na-ejikọta ya site n'usoro usoro oxime-ligation siri ike iji nweta ọtụtụ conjugates antibody-anti-homogenous (ADCs) dị nso-homogene na nke 2. Ndị agha conjugates ahụ na-egosipụta ezi pharmacokinetic Njirimara, ike na vitro cytotoxic ọrụ megide HERXNUMX + sel cancer. Ọ bụrụ na e jiri ya tụnyere ADC nke kwadoro site na cysteine ​​alkylation na-esote mbelata nke diskeride interchain, a na-egosiputa na ADCs nke amino-acid na-ejighị ya na-eme ihe na-egosi na enwekwuola cytotoxicity in vitro

Na Vivi: Njikọ ndị na-aṅụ ọgwụ ọjọọ (ADCs) na-egosi nrụpụta tumọ zuru ezu na nsí. Ha na-enwekwa ihe omuma na-abawanye uru na oke.


Esi zụta MMAD; zuta Demethyldolastatin 10 si AASraw

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