Ihe niile banyere Mibolerone (Lelee tụlee)

1.Wa bụ IDFP (615250-02-7)
2.How ka IDFP (615250-02-7) na-arụ ọrụ?
3.IDFP (615250-02-7) mmetụta
4.IDFP (615250-02-7) usoro onunu
5. IDFP (615250-02-7) ịdọ aka ná ntị
6.IDFP (615250-02-7) nyocha


Video IDFP


I.IDFP isi agwa:

aha: IDFP
CAS: 615250-02-7
Molekụla Formula: C15H32FO2P
Ọbara arọ: 294.391
Melt Point:
Nchekwa Nche: -20 ° C
agba:


1. Kedu ihe bụ IDFP (615250-02-7)aasraw

IDFP(615250-02-7), bụ akụkụ nke organophosphorus nke metụtara nhụjuanya na-ahụ maka nerve sarin. Aha njirimara gụnyere: IDFP; ISOPROPYL DODECYLFLUOROPHOSPHONATE; P-DODECYL-1-METHYLETHYL ESTER-PHOSPHONOFLUORIDIC ACID; 1- [fluoro (propan-2-yloxy) phosphoryl] dodecane.

IDFP (615250-02-7) Nkọwapụta Chemical
aha IDPF, ISOPROPYL DODECYLFLUOROPHOSPHONATE
CAS 615250-02-7
molekụla Formula C15H32FO2PIDFP (615250-02-7)
molekụla arọ 294.391
nchekwa temp -20 ° C
Decription IDFP bụ otu akụkụ nke organophosphorus nke metụtara ndị na-agwọ ọrịa ahụ sarin. Dị ka sarin, IDFP bụ onye na-enweghị mgbagha na-apụghị ịgbagha agbagha maka ọtụtụ enzymes dị iche iche nke na-emekarị ka ọ ghara ịkụda ndị neurotransmitters
ọdịdị Ntụ ntụ
Factory www.aasraw.com


2. Kedu ka IDFP (615250-02-7) si arụ ọrụ?aasraw

Endocannabinoids, 2-arachidonoyl glycerol (2-AG) na arachidonoyl ethanolamide (AEA), bụ lipids na-arụ ọrụ nke na-achịkwa ọrụ dịgasị iche iche na arụ ọrụ metabolic site na ịmepụta ndị na-anabata cannabinoid, central cannabinoid (CB1) na cannabinoid elu (CB2). Monoacylglycerol lipase (MAGL) na fatty acid amide hydrolase (FAAH) na-agbanye 2-AG na AEA, wee kwụsị ọrụ ha. IDFP (615250-02-7) bụ akụkụ nke organophosphorus nke na - ejichikarị MAGL na FAAH na 50 na 0.8 nM, respectively.3 Na 1 mg / kg, IDFP na - ebuli ụbụrụ nke 10-AG na AEA karịa 2- agwakọta, na mbelata ogo nke arachidonic acid site na oke nha.

Nzuzo IDFP uzo (615250-02-7) hplc =98% | AASraw ntụ ntụ


3. IDFP (615250-02-7) mmetụtaaasraw

Mmebi omume behavinoid CB1 na-adabere

Gịnị bụ IDFP (615250-02-7)mmetụta? N'ime 5 min mgbe a gwọchara ya na IDFP (10 mg kg-1, ip), ụmụ irighiri ihe dị mma ma nọgide na-enweghị nchegharị na anya ha. Ọnọdụ a na-emeghị ihe na-emetụtakarị mmeghachi omume omume nke ndị CBonNUMX agonists ziri ezi, nke mere ka anyị nyochaa ụmụ anụmanụ na-emeso IDFP na nyocha tetrad maka àgwà cannabinoid. A chọtara IDFP iji mepụta mmetụta anọ ọ bụla a na-atụ anya ya site na-akpali akpali CB1-hypomotility, analgesia, catalepsy na hypothermia. A na-egbochi mmetụta omume ndị a site na mmepe nke onye na-akwado AM1 na-akwado CB1 na ndị na-anọghị na CB25120 (- / -) ụmụ oke na 1. Nsonaazụ ndị a na-egosi na igbochi endabannabinoid metabolism bụ maka ọrụ emepụtara nke IDFP mmetụta. Mmetụta dị ukwuu nke mmetụta dị na IDFP yiri nke ahụ na onye agonist CB21 kpọmkwem, WIN1-55212 (2 mg kg-10, ip). N'iji mgbatị akpụkpọ anụ ụbụrụ yiri nke ahụ, IDFP na-ekesa CB1 agonist ejiri na IC1 nke 50 nM2, yiri IC17 maka MAGL (50 nM) na FAAH (0.8 nM), ebe ọbụnadị na 3 nM ọ pụtaghị (30 ± 5%, n = 9, p> 6) na-akpali guanosine triphosphate adịchi. Nke a na-egosi na IDFP emetụtaghị na-eme ka onye agonist na-anabata ihe na-adabere na ya.

Ihe IDFP

Nkwụsịtụ nke endocannabinoid metabolism na vivo

A na-enyocha ihe ndị a na-eme site na IDFP- (10 mg kg-1, ip) na ụmụ oke ndị nwere ụgbọala. Achọpụtara usoro ọgwụgwọ a maka IDFP site na mmekọrịta mmeghachi omume-mmeghachi omume maka ịmepụta àgwà nke cannabinoid. N'ihe anọ, post-ọgwụgwọ, XYUMX-AG na anandamide na-egbochi ikuku mmiri site na 2 ± 86% na 1 ± 94%, n'ụdị, n'ụbụrụ ụbụrụ sitere na anụmanụ ndị a na-emeso IDFP. N'ụzọ dị iche, ọ dịghị nchọpụta a chọpụtara na AChE hụrụ na IDFP na otu nnwale ahụ, na-enweghi nkwenye nke cholinergic. IDFP bụ anallọg ogologo nke ogologo nke sarin na dodecyl dochie methyl, mgbanwe nke na - akpata ike imechi AChE.

Mbelata nke arụmọrụ hydrolytic endocannabinoid hụrụ na ụbụrụ anụ ahụ nke anụmanụ IDFP jikọtara ya na ihe karịrị 10-na-amụba ụbụrụ n'ụbụrụ nke ma 2-AG ma gbanwee. A na-ahụkwa ụdị mgbanwe ndị ọzọ na ụbụrụ na-ahụ maka ọrịa NF-acylethanolamines (Ụdị) (eg, N-palmitoyl- na N-oleoylethanolamines na monoacylglycerols [2-na 1-palmitoylglycerol na 2- na 1-oleoylglycerol]. N'ụzọ na-adọrọ mmasị, IDFP belatatara ogo AA na ọnụahịa dị ka elu elepụtara maka 2-AG. Ihe ndekọ ndị a na-egosi na IDFP bụ onye na-egbochi 2-AG na ihe mgbakwasị ụkwụ na-eme ihe na vivo, na-eduga n'ụbụrụ ụbụrụ dị elu nke ma endocannabinoids na ọnụma nke ọnụ na free AA.

IDFP usoro onunu ogwu


4. IDFP (615250-02-7) usoro onunuaasraw

Maka nchekwa ogologo oge, anyị na-atụ aro na IDFP usoro onunu ogwu a ga-echekwa dị ka enye na -20 ℃. Ọ ghaghị ịdịgide ma ọ dịkarịa ala otu afọ.
A na-enye IDFP ka ọ bụrụ ngwọta na methyl acetate. Iji gbanwee ihe mgbaze ahụ, kpochasịa methyl acetate n'okpuru mmiri dị nwayọọ nke nitrogen ma gbakwunye ihe nkwụsị nke ndị na - ahọrọ. Ndị na - emepụta ihe dịka ethanol, DMSO, na dimethyl formamide nwere ike iji gas jupụtara. Solubility nke IDFP na ihe mgbaze ndị a bụ ihe dịka 10mg / ml.
Ọ bụrụ na achọrọ ọgwụ ngwọta maka nyocha nke ndụ, a ga-edozi ha kachasị mma site na ịmegharị ihe na-emepụta ihe n'ime ihe ndị na-edozi ahụ ma ọ bụ saline isotonic.Nọpụta na ihe ndị dị ndụ na-enweghị ihe ọ bụ, ebe ọ bụ na ihe ndị na-emepụta ihe nwere ike inwe mmetụta nrịanrịa na obere ihe. adighi akwado itinye ihe ngwọta nke otutu ihe kariri otu ubochi.


5. IDFP (615250-02-7) ịdọ aka ná ntịaasraw

IDFP (615250-02-7) abụghị maka mmadụ ma ọ bụ ọgwụ ogwu, ịdọ aka ná ntị ka na-eme nchọpụta. Zere iso gị na akpụkpọ anụ, anya, akụkụ iku ume, nsogbu ọ bụla, kpọọ dọkịta gị ozugbo.


6. IDFP (615250-02-7) nyochaaasraw

IDFP (615250-02-7) bụ otu akụkụ organophosphorus nke metụtara ọrụ nerve ahụ. Dị ka sarin, IDFP bụ onye na-enweghị ike igbochi ya maka ọtụtụ enzymes dị iche iche nke na-emekarị ka ọ ghara ịkụda ndị na-ahụ maka ntanet, ọ bụ ezie na ụdị IDFP dị ogologo na-eme ka ọ dị ike dị ka onye na-emechi acetylcholinesterase (AChE), na IC50 nke naanị 6300nM, ọ bụ onye nwere ike inhibitor abụọ enzymes monoacylglycerol lipase (MAGL), bụ isi enzyme nke na-eweda 2-arachidonoylglycerol endocannabinoid (2-AG), na fatty acid amide hydrolase (FAAH), nke bụ isi enzyme nke na-emebi isi isi endocannabinoid anandamide . Ihe IC50 nke IDFP bụ 0.8nM na MAGL, na 3.0nM na FAAH. Mgbochi nke enzymes abụọ a na-eme ka ụba dị elu nke maandandide na 2-AG n'ime ụbụrụ, na-ebute ụba nke cannabinoid na mmetụta omume nke cannabinoid dị na ọmụmụ ụmụ anụmanụ, ebe ọ na-enweghị ike na AChE, ọ pụtaghị na a na-emepụta mgbaàmà cholinergic. usoro ihe yiri nke ya na ndị na-ahụ maka nerve a machibidoro iwu, ụdị nke IDFP dị ogologo na-eme ka ọ daa ná mpụga nkọwa nke "kemịkal na-egbu egbu" n'okpuru Nkwekọrịta Ngwá Agha Chemical, na ebe ọ na-egosipụtakwa ihe ngosi AChE nwere ike nke ogige organophosphorus, IDFP (615250-02-7) nyocha adịghị n'okpuru otu njikwa iwu.


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Ntughari 1 Response

  • mereupregatit07 / 18 / 2018 na 7: 43 am

    Daalụ !! nwee olileanya na $$ gị na-aga nke ọma! Ahịa ọgwụ na ntanetị