N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide

N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamid powder bụ piperazinyl phenyl urea nke usoro ya dị iche na alkyl carbamates na alpha-keto heterocyclic ogige nakwa na ọ bụ onye na-eme ihe na-edozi ike nke fatty acid amide hydrolase (FAAH) (IC50s = 34 na 33 nM na oke na ụmụ mmadụ, nke nwere ike ịgafe ụbụrụ ọbara barrier.1 Na 20 mg / kg, jikọrọ aka na saịtị arụ ọrụ nke FAAH site na nkedo nke ọrụ urea nke na-emepụta aniline na FAAH-poperazinyl carbamate.

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Product Description

 

N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide video

 

 


 

I.N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide basic Characters:

 

aha: N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
CAS: 681136-29-8
Ịdị ọcha: ≥99% (HPLC)
Synonyms: JNJ 1661010;N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide;Takeda-25;1-Piperazinecarboxamide, N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-;JNJ 1661010, >=98%
Ụdị Mkpụrụkpụ: C19H19N5OS
Ọbara arọ: 365.459
Ebe na-agbaze: 240.48
Isi okwu: 559.69 Celsius C na 760 mmHg
njupụta: ~ 1.3 g / cm3
Nchekwa Nche: Na-echekwa na + 4 Celsius C
Solubility: DMSO: ≥28mg / mL
Ntughari ihe omuma: N20D 1.68
agba: A crystalline siri ike
InChI: InChI=1S/C19H19N5OS/c25-18(20-16-9-5-2-6-10-16)23-11-13-24(14-12-23)19-21-17(22-26-19)15-7-3-1-4-8-15/h1-10H,11-14H2,(H,20,25)
KeyInChI: BHBOSTKQCZEAJM-UHFFFAOYSA-N

 


 

II. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid Utu ojiji na okirikiri:

1.Name:

N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid ntụ ntụ, JNJ 166101 ntụ ntụ

2.How bu oru na N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid Powder use?

FAAH nọ na JNJ-1661010 na-atụ aro ngwa ngwa nke mkparịta ụka dị n'etiti JNJ1661010 na saịtị na-arụ ọrụ, nke a na-emewanye na okpomọkụ dị elu. JNJ-1661010 bụ onye na-arụ ọrụ na-arụ ọrụ, dịka nyochaa site na LC-ESI-MS. Ngwurugwu JNJ-1661010 na phenylthiadiazole na ọdọ mmiri hydrophobic na phenylurea dị na akpa hydrophilic nke FAAH, JNJ-1661010 (20 mg / kg ip) na-egbochi FAAH site ma ọ dịkarịa ala 85% maka ruo 4 h mgbe dosing, nchịkọta nke egbugbere ọnụ ethanolamides na ụbụrụ ụbụrụ. Ngwunye JNJ-1661010-na-adabere n'ụzọ dị irè iji chepụta allodynia nke kachasị rụọ ọrụ nke 90% na 30 min kwadoro na Mild Thermal Result (MTI) ụmụ oke na oke oke. JNJ-1661010 (20 mg / kg) na-agbanwe agbanwe site na 60.8% na 30 min na ụbụrụ na-agwọ ọrịa na-egbu egbu. JNJ-1661010 (50 mg / kg ip) na-egosi nrịtapụta dị ịrịba ama nke hyperalgesia na 30 min kwadoro na ụdị carrageenan rat na-egbu mgbu.
Rats na JNJ-1661010 (20 mg / kg ip) nwere Cmax nke 26.9 μM plasma na Tmax nke 0.75 h na Cmax na ụbụrụ nke 6.04 μM na Tmax nke 2 h. JNJ-1661010 (20 mg / kg ip) na - egbochi ụbụrụ FAAH ma bulie AEA larịị na ụbụrụ ụbụrụ na oke.

3.Warning on N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid powder

4.Further ntụziaka:

5. N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamid Powder:

Min iji 10grams.
Ajuju ajuju nke di n'ogo (N'ime 1kg) nwere ike iziputa na 12 awa mgbe ugwo.
Maka usoro ka ukwuu (N'ime 1kg) nwere ike zipụ na 3 ụbọchị ọrụ mgbe ịkwụ ụgwọ.

6. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid ntụ ntụ ntụziaka:

Ịjụ ajụjụ maka ndị na - anọchite anya anyị (CSR) maka nkọwa, maka amaokwu gị.

7. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid powder Marketing:

A ga-enye ha n'ọdịnihu na-abịa.

 


 

III. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamide ntụ ntụ HNMR

 

Anyị bụ ndị na-enweghị ntụsara ahụ, Preditting powder for sale, Raw Aprepitant powder (170729-80-3) hplc >98% | AASraw R & D Reagents

 


 

IV. Esi zụta N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamide powder from AASraw?

 

1.To kpọtụrụ anyị site na email anyịusoro nyocha, ma ọ bụ skypeonye na-ahụ maka ndị ahịa (CSR).
2.To nye anyị ọnụọgụgụ na adreesị gị.
3.OUR CSR ga-enye gị nkọwa, okwu nkwụ ụgwọ, nọmba nchịkọta, ụzọ nnyefe na ụbọchị mbata echere (ETA).
4.Bayment done and the goods will be sent out na 12 awa (N'ihi na iwu n'ime 10kg).
5.Goods natara ma kwuo ihe.

 


 

Chọpụta ihe kacha amasị gị:

 

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